A Forward Genetic Screen Targeting the Endothelium Reveals a Regulatory Role for the Lipid Kinase Pi4ka in Myelo- and Erythropoiesis

A Forward Genetic Screen Targeting the Endothelium Reveals a Regulatory Role for the Lipid Kinase Pi4ka in Myelo- and Erythropoiesis

Summary: Given its role as the source of definitive hematopoietic cells, we sought to determine whether mutations initiated in the hemogenic endothelium would yield hematopoietic abnormalities or malignancies. Here, we find that endothelium-specific transposon mutagenesis in mice promotes hematopoie...

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Detalles Bibliográficos
Autores principales: Safiyyah Ziyad, Jesse D. Riordan, Ann M. Cavanaugh, Trent Su, Gloria E. Hernandez, Georg Hilfenhaus, Marco Morselli, Kristine Huynh, Kevin Wang, Jau-Nian Chen, Adam J. Dupuy, M. Luisa Iruela-Arispe
Formato: Artículo
Lenguaje:English
Publicado: Elsevier 2018-01-01
Colección:Cell Reports
Acceso en línea:http://www.sciencedirect.com/science/article/pii/S2211124718300342

Internet

http://www.sciencedirect.com/science/article/pii/S2211124718300342

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