Mitohormesis during advanced stages of Duchenne muscular dystrophy reveals a redox-sensitive creatine pathway that can be enhanced by the mitochondrial-targeting peptide SBT-20

Mitohormesis during advanced stages of Duchenne muscular dystrophy reveals a redox-sensitive creatine pathway that can be enhanced by the mitochondrial-targeting peptide SBT-20

Mitochondrial creatine kinase (mtCK) regulates the “fast” export of phosphocreatine to support cytoplasmic phosphorylation of ADP to ATP which is more rapid than direct ATP export. Such “creatine-dependent” phosphate shuttling is attenuated in several muscles, including the heart, of the D2.mdx mous...

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Bibliographic Details
Main Authors: Meghan C. Hughes, Sofhia V. Ramos, Aditya N. Brahmbhatt, Patrick C. Turnbull, Nazari N. Polidovitch, Madison C. Garibotti, Uwe Schlattner, Thomas J. Hawke, Jeremy A. Simpson, Peter H. Backx, Christopher GR. Perry
Format: Article
Language:English
Published: Elsevier 2024-10-01
Series:Redox Biology
Subjects:
Mitochondria
Muscle
Antioxidant
Respiration
Creatine
Small molecule therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231724002970

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http://www.sciencedirect.com/science/article/pii/S2213231724002970

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