TM6SF2 E167K variant decreases PNPLA3-mediated PUFA transfer to promote hepatic steatosis and injury in MASLD

TM6SF2 E167K variant decreases PNPLA3-mediated PUFA transfer to promote hepatic steatosis and injury in MASLD

Backgrounds/Aims Transmembrane 6 superfamily member 2 (TM6SF2) E167K variant is closely associated with the occurrence and development of metabolic dysfunction-associated steatotic liver disease (MASLD). However, the role and mechanism of TM6SF2 E167K variant during MASLD progression are not yet ful...

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Bibliographic Details
Main Authors: Baokai Sun, Xiaoqian Ding, Jie Tan, Jie Zhang, Xueru Chu, Shuimi Zhang, Shousheng Liu, Zhenzhen Zhao, Shiying Xuan, Yongning Xin, Likun Zhuang
Format: Article
Language:English
Published: Korean Association for the Study of the Liver 2024-10-01
Series:Clinical and Molecular Hepatology
Subjects:
transmembrane 6 superfamily member 2
patatin-like phospholipase domain-containing protein 3
polyunsaturated fatty acids
hepatic steatosis
metabolic dysfunction-associated steatotic liver disease
Online Access:http://e-cmh.org/upload/pdf/cmh-2024-0268.pdf

Internet

http://e-cmh.org/upload/pdf/cmh-2024-0268.pdf

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