Distinct melanocyte subpopulations defined by stochastic expression of proliferation or maturation programs enable a rapid and sustainable pigmentation response.

Distinct melanocyte subpopulations defined by stochastic expression of proliferation or maturation programs enable a rapid and sustainable pigmentation response.

The ultraviolet (UV) radiation triggers a pigmentation response in human skin, wherein, melanocytes rapidly activate divergent maturation and proliferation programs. Using single-cell sequencing, we demonstrate that these 2 programs are segregated in distinct subpopulations in melanocytes of human a...

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Bibliographic Details
Main Authors: Ayush Aggarwal, Ayesha Nasreen, Babita Sharma, Sarthak Sahoo, Keerthic Aswin, Mohammed Faruq, Rajesh Pandey, Mohit K Jolly, Abhyudai Singh, Rajesh S Gokhale, Vivek T Natarajan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-08-01
Series:PLoS Biology
Online Access:https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3002776&type=printable

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https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3002776&type=printable

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