Study protocol for a randomised pragmatic trial comparing the clinical and cost effectiveness of lithium and quetiapine augmentation in treatment resistant depression (the LQD study)

Study protocol for a randomised pragmatic trial comparing the clinical and cost effectiveness of lithium and quetiapine augmentation in treatment resistant depression (the LQD study)

Abstract Background Approximately 30–50% of patients with major depressive disorder can be classed as treatment resistant, widely defined as a failure to respond to two or more adequate trials of antidepressants in the current episode. Treatment resistant depression is associated with a poorer progn...

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Bibliographic Details
Main Authors: L. Marwood, R. Taylor, K. Goldsmith, R. Romeo, R. Holland, A. Pickles, J. Hutchinson, D. Dietch, A. Cipriani, R. Nair, M.-J. Attenburrow, A. H. Young, J. Geddes, R. H. McAllister-Williams, A. J. Cleare
Format: Article
Language:English
Published: BMC 2017-06-01
Series:BMC Psychiatry
Subjects:
Treatment resistant depression
Lithium
Quetiapine
Pragmatic
Randomised clinical trial
Longitudinal
Online Access:http://link.springer.com/article/10.1186/s12888-017-1393-0

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http://link.springer.com/article/10.1186/s12888-017-1393-0

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