A Theranostic Nanocomplex Combining with Magnetic Hyperthermia for Enhanced Accumulation and Efficacy of pH-Triggering Polymeric Cisplatin(IV) Prodrugs

A Theranostic Nanocomplex Combining with Magnetic Hyperthermia for Enhanced Accumulation and Efficacy of pH-Triggering Polymeric Cisplatin(IV) Prodrugs

Although polymeric platinum(IV) (Pt(IV)) prodrugs can reduce the side effects of cisplatin, the efficacy of the prodrug is still limited by its non-targeted distribution, poor penetration in deep tumor tissue, and low cytotoxicity in tumor cells. To improve the clinical potential of polymeric prodru...

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Bibliographic Details
Main Authors: Yang Qu, Zhiqi Wang, Miao Sun, Tian Zhao, Xuanlei Zhu, Xiaoli Deng, Man Zhang, Ying Xu, Hongfei Liu
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Pharmaceuticals
Subjects:
polymeric prodrug
theranostic nanocomplex
pH-triggering releasing
magnetic targeting
magnetic hyperthermia
magnetic resonance imaging
Online Access:https://www.mdpi.com/1424-8247/15/4/480

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https://www.mdpi.com/1424-8247/15/4/480

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