Activation of hedgehog signaling in mesenchymal stem cells induces cartilage and bone tumor formation via Wnt/β-Catenin

Activation of hedgehog signaling in mesenchymal stem cells induces cartilage and bone tumor formation via Wnt/β-Catenin

Indian Hedgehog (IHH) signaling, a key regulator of skeletal development, is highly activated in cartilage and bone tumors. Yet deletion of Ptch1, encoding an inhibitor of IHH receptor Smoothened (SMO), in chondrocyte or osteoblasts does not cause tumorigenesis. Here, we show that Ptch1 deletion in...

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Bibliographic Details
Main Authors: Qi Deng, Ping Li, Manju Che, Jiajia Liu, Soma Biswas, Gang Ma, Lin He, Zhanying Wei, Zhenlin Zhang, Yingzi Yang, Huijuan Liu, Baojie Li
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-09-01
Series:eLife
Subjects:
hedgehog
bone tumor
mesenchymal stem cell
Online Access:https://elifesciences.org/articles/50208

Internet

https://elifesciences.org/articles/50208

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