Rapamycin, by Inhibiting mTORC1 Signaling, Prevents the Loss of Striatal Bidirectional Synaptic Plasticity in a Rat Model of L-DOPA-Induced Dyskinesia

Rapamycin, by Inhibiting mTORC1 Signaling, Prevents the Loss of Striatal Bidirectional Synaptic Plasticity in a Rat Model of L-DOPA-Induced Dyskinesia

Levodopa (L-DOPA) treatment is the main gold-standard therapy for Parkinson disease (PD). Besides good antiparkinsonian effects, prolonged use of this drug is associated to the development of involuntary movements known as L-DOPA-induced dyskinesia (LID). L-DOPA-induced dyskinesia is linked to a sen...

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Bibliographic Details
Main Authors: Valeria Calabrese, Anna Di Maio, Gioia Marino, Antonella Cardinale, Giuseppina Natale, Arianna De Rosa, Federica Campanelli, Maria Mancini, Francesco Napolitano, Luigi Avallone, Paolo Calabresi, Alessandro Usiello, Veronica Ghiglieri, Barbara Picconi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Aging Neuroscience
Subjects:
depotentiation
functional plasticity
levodopa-induced dyskinesia
Parkinson’s disease
dorsolateral striatum
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2020.00230/full

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https://www.frontiersin.org/article/10.3389/fnagi.2020.00230/full

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