The double edge of anti-CD40 siRNA therapy: It increases renal microcapillar density but favours the generation of an inflammatory milieu in the kidneys of ApoE −/− mice

The double edge of anti-CD40 siRNA therapy: It increases renal microcapillar density but favours the generation of an inflammatory milieu in the kidneys of ApoE −/− mice

Abstract Background Chronic kidney disease (CKD) is associated with endothelial dysfunctions thus prompting links between microcirculation (MC), inflammation and major cardiovascular risk factors. Purpose of the study We have previously reported that siRNA-silencing of CD40 (siCD40) reduced atherosc...

Full description

Bibliographic Details
Main Authors: Miguel Hueso, Angela Casas, Adrian Mallén, Laura de Ramón, Nuria Bolaños, Cristian Varela, Josep M. Cruzado, Joan Torras, Estanislao Navarro
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Journal of Inflammation
Subjects:
siRNA therapy
Off-target side effects
Inflammatory milieu
Kidney
Atherosclerosis
Macrophage infiltration
Online Access:https://doi.org/10.1186/s12950-019-0228-9

Internet

https://doi.org/10.1186/s12950-019-0228-9

Similar Items