Iron overload and chelation modulates bisretinoid levels in the retina

Iron overload and chelation modulates bisretinoid levels in the retina

AimIron dysregulation in conjunction with other disease processes may exacerbate retinal degeneration. We employed models of iron overload and iron chelation to explore the interactions between iron-catalyzed oxidation and photoreactive bisretinoid lipofuscin.MethodsThe mice were injected intravitre...

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Bibliographic Details
Main Authors:	Jin Zhao, Hye Jin Kim, Diego Montenegro, Josh L. Dunaief, Janet R. Sparrow
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-12-01
Series:	Frontiers in Ophthalmology
Subjects:	iron photoreceptor cells retinal pigment epithelium intravitreal injection bisretinoid vitamin A visual cycle
Online Access:	https://www.frontiersin.org/articles/10.3389/fopht.2023.1305864/full

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