PEPT1-mediated prodrug strategy for oral delivery of peramivir

PEPT1-mediated prodrug strategy for oral delivery of peramivir

Peramivir was a novel and highly potent neuraminidase (NA) inhibitor for the treatment of influenza A and B. However, it exhibited a very low oral bioavailability (only 3%) due to the high polarity (log P of −1.4) and the low membrane permeability across the intestine. To utilize the PEPT1-mediated...

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Bibliographic Details
Main Authors: Yongbing Sun, Wei Gan, Mingdao Lei, Wei Jiang, Meng Cheng, Junwei He, Qi Sun, Wan Liu, Lvjiang Hu, Yi Jin
Format: Article
Language:English
Published: Elsevier 2018-11-01
Series:Asian Journal of Pharmaceutical Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1818087618300308

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http://www.sciencedirect.com/science/article/pii/S1818087618300308

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