Regulation of DNA Double Strand Breaks Processing: Focus on Barriers

Regulation of DNA Double Strand Breaks Processing: Focus on Barriers

In all the eukaryotic cells, nucleolytic processing (resection) of a double strand DNA break (DSB) is a key step to channel the repair of the lesion toward the homologous recombination, at the expenses of the non-homologous end joining (NHEJ). The coordinated action of several nucleases and helicase...

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Bibliographic Details
Main Authors: Federica Marini, Chetan C. Rawal, Giordano Liberi, Achille Pellicioli
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Molecular Biosciences
Subjects:
resection barriers
DSB processing
NHEJ
HDR
DNA:RNA hybrid
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2019.00055/full

Internet

https://www.frontiersin.org/article/10.3389/fmolb.2019.00055/full

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