Evolution of chemistry and selection technology for DNA-encoded library

Evolution of chemistry and selection technology for DNA-encoded library

DNA-encoded chemical library (DEL) links the power of amplifiable genetics and the non-self-replicating chemical phenotypes, generating a diverse chemical world. In analogy with the biological world, the DEL world can evolve by using a chemical central dogma, wherein DNA replicates using the PCR rea...

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Bibliographic Details
Main Authors: Peixiang Ma, Shuning Zhang, Qianping Huang, Yuang Gu, Zhi Zhou, Wei Hou, Wei Yi, Hongtao Xu
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Acta Pharmaceutica Sinica B
Subjects:
DNA-encoded library
Drug discovery
High-throughput selection
DNA-compatible synthesis
In vitro evolution
Chemical central dogma
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383523003842

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http://www.sciencedirect.com/science/article/pii/S2211383523003842

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