Autoimmunity to synovial extracellular matrix proteins in patients with postinfectious Lyme arthritis

Autoimmunity to synovial extracellular matrix proteins in patients with postinfectious Lyme arthritis

BACKGROUND Autoimmune diseases often have strong genetic associations with specific HLA-DR alleles. The synovial lesion in chronic inflammatory forms of arthritis shows marked upregulation of HLA-DR molecules, including in postinfectious Lyme arthritis (LA). However, the identity of HLA-DR–presented...

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Bibliographic Details
Main Authors: Korawit Kanjana, Klemen Strle, Robert B. Lochhead, Annalisa Pianta, Laura M. Mateyka, Qi Wang, Sheila L. Arvikar, David E. Kling, Cameron A. Deangelo, Lucy Curham, Alan G. Barbour, Catherine E. Costello, James J. Moon, Allen C. Steere
Format: Article
Language:English
Published: American Society for Clinical Investigation 2023-09-01
Series:The Journal of Clinical Investigation
Subjects:
Autoimmunity
Infectious disease
Online Access:https://doi.org/10.1172/JCI161170

Internet

https://doi.org/10.1172/JCI161170

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