Docosahexaenoic acid synthesis from n-3 polyunsaturated fatty acids in differentiated rat brain astrocytes

Docosahexaenoic acid synthesis from n-3 polyunsaturated fatty acids in differentiated rat brain astrocytes

DHA, the main n-3 PUFA in the brain, is synthesized from n-3 PUFA precursors by astrocytes. To assess the potential of this process to supply DHA for the brain, we investigated whether the synthesis in astrocytes is dependent on DHA availability. Rat brain astrocytes differentiated with dibutyryl cA...

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Bibliographic Details
Main Authors: Deborah E. Williard, Shawn D. Harmon, Terry L. Kaduce, Meredith Preuss, Steven A. Moore, Michael E.C. Robbins, Arthur A. Spector
Format: Article
Language:English
Published: Elsevier 2001-09-01
Series:Journal of Lipid Research
Subjects:
α-linolenic acid
docosapentaenoic acid
tetracosapentaenoic acid
tetracosahexaenoic acid
cAMP
elongation
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520302686

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http://www.sciencedirect.com/science/article/pii/S0022227520302686

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