Interplay between VSD, pore, and membrane lipids in electromechanical coupling in HCN channels

Interplay between VSD, pore, and membrane lipids in electromechanical coupling in HCN channels

Hyperpolarized-activated and cyclic nucleotide-gated (HCN) channels are the only members of the voltage-gated ion channel superfamily in mammals that open upon hyperpolarization, conferring them pacemaker properties that are instrumental for rhythmic firing of cardiac and neuronal cells. Activation...

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Bibliographic Details
Main Authors: Ahmad Elbahnsi, John Cowgill, Verena Burtscher, Linda Wedemann, Luise Zeckey, Baron Chanda, Lucie Delemotte
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-06-01
Series:eLife
Subjects:
molecular modeling
molecular dynamics simulations
voltage-gated ion channel
electromechanical coupling
lipid-protein interaction
Online Access:https://elifesciences.org/articles/80303

Internet

https://elifesciences.org/articles/80303

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