Relationship between Brain Metabolic Disorders and Cognitive Impairment: LDL Receptor Defect

Relationship between Brain Metabolic Disorders and Cognitive Impairment: LDL Receptor Defect

The low-density-lipoprotein receptor (<i>LDLr</i>) removes low-density lipoprotein (LDL), an endovascular transporter that carries cholesterol from the bloodstream to peripheral tissues. The maintenance of cholesterol content in the brain, which is important to protect brain function, is...

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Bibliographic Details
Main Authors: Dong-Yong Hong, Dong-Hun Lee, Ji-Young Lee, Eun-Chae Lee, Sang-Won Park, Man-Ryul Lee, Jae-Sang Oh
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:International Journal of Molecular Sciences
Subjects:
cholesterol metabolism
<i>LDLr</i>
insulin receptor
<i>SREBP</i>
blood–brain-barrier (BBB) breakdown
neuroinflammation
Online Access:https://www.mdpi.com/1422-0067/23/15/8384

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https://www.mdpi.com/1422-0067/23/15/8384

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