Effect of adaptive laboratory evolution of engineered Escherichia coli in acetate on the biosynthesis of succinic acid from glucose in two-stage cultivation

Effect of adaptive laboratory evolution of engineered Escherichia coli in acetate on the biosynthesis of succinic acid from glucose in two-stage cultivation

Abstract Escherichia coli MLB (MG1655 ΔpflB ΔldhA), which can hardly grow on glucose with little succinate accumulation under anaerobic conditions. Two-stage fermentation is a fermentation in which the first stage is used for cell growth and the second stage is used for product production. The abili...

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Bibliographic Details
Main Authors: Jiaping Jiang, Yuanchan Luo, Peng Fei, Zhengtong Zhu, Jing Peng, Juefeng Lu, Du Zhu, Hui Wu
Format: Article
Language:English
Published: SpringerOpen 2024-04-01
Series:Bioresources and Bioprocessing
Subjects:
Adaptive laboratory evolution
E. coli
Acetate
Succinic acid
Two-stage fermentation
Online Access:https://doi.org/10.1186/s40643-024-00749-5

Internet

https://doi.org/10.1186/s40643-024-00749-5

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