Tumors carrying BRAF-mutations over-express NAMPT that is genetically amplified and possesses oncogenic properties

Tumors carrying BRAF-mutations over-express NAMPT that is genetically amplified and possesses oncogenic properties

Abstract Background Nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in nicotinamide adenine dinucleotide (NAD) biosynthesis, is up-regulated in several cancers, including metastatic melanoma (MM). The BRAF oncogene is mutated in different cancer types, among which MM and thy...

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Bibliographic Details
Main Authors: Valentina Audrito, Enrico Moiso, Filippo Ugolini, Vincenzo Gianluca Messana, Lorenzo Brandimarte, Ilaria Manfredonia, Simonetta Bianchi, Francesco De Logu, Romina Nassini, Anna Szumera-Ciećkiewicz, Daniela Taverna, Daniela Massi, Silvia Deaglio
Format: Article
Language:English
Published: BMC 2022-03-01
Series:Journal of Translational Medicine
Subjects:
NAMPT
Oncogene
Transformation
BRAF oncogenic signaling
MAPK
NAMPT inhibitors
Online Access:https://doi.org/10.1186/s12967-022-03315-9

Internet

https://doi.org/10.1186/s12967-022-03315-9

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