Establishing the Link between X-Chromosome Aberrations and <i>TP53</i> Status, with Breast Cancer Patient Outcomes

Establishing the Link between X-Chromosome Aberrations and <i>TP53</i> Status, with Breast Cancer Patient Outcomes

Ubiquitous to normal female human somatic cells, X-chromosome inactivation (XCI) tightly regulates the transcriptional silencing of a single X chromosome from each pair. Some genes escape XCI, including crucial tumour suppressors. Cancer susceptibility can be influenced by the variability in the gen...

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Bibliographic Details
Main Authors: Franco Caramia, Terence P. Speed, Hui Shen, Ygal Haupt, Sue Haupt
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Cells
Subjects:
X chromosome
XCI
breast cancer
TP53
TCGA
METABRIC
Online Access:https://www.mdpi.com/2073-4409/12/18/2245

Internet

https://www.mdpi.com/2073-4409/12/18/2245

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