Establishing the Link between X-Chromosome Aberrations and <i>TP53</i> Status, with Breast Cancer Patient Outcomes
Ubiquitous to normal female human somatic cells, X-chromosome inactivation (XCI) tightly regulates the transcriptional silencing of a single X chromosome from each pair. Some genes escape XCI, including crucial tumour suppressors. Cancer susceptibility can be influenced by the variability in the gen...
Main Authors: | Franco Caramia, Terence P. Speed, Hui Shen, Ygal Haupt, Sue Haupt |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2023-09-01
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Series: | Cells |
Subjects: | |
Online Access: | https://www.mdpi.com/2073-4409/12/18/2245 |
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