Low HOX gene expression in PML-RARα-positive leukemia results from suppressed histone demethylation

Low HOX gene expression in PML-RARα-positive leukemia results from suppressed histone demethylation

Homeobox (HOX) genes are frequently dysregulated in leukemia. Previous studies have shown that aberrant HOX gene expression accompanies leukemogenesis and affects disease progression and leukemia patient survival. Patients with acute myeloid leukemia (AML) bearing PML-RARα fusion gene have distinct...

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Bibliographic Details
Main Authors: Katerina Rejlova, Alena Musilova, Karolina Skvarova Kramarzova, Marketa Zaliova, Karel Fiser, Meritxell Alberich-Jorda, Jan Trka, Julia Starkova
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:Epigenetics
Subjects:
homeobox genes
leukemia
pml-rarα
gene expression
histone demethylase
histone modifications
Online Access:http://dx.doi.org/10.1080/15592294.2017.1413517

Internet

http://dx.doi.org/10.1080/15592294.2017.1413517

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