Ac-SDKP attenuates ER stress-stimulated collagen production in cardiac fibroblasts by inhibiting CHOP-mediated NF-κB expression

Ac-SDKP attenuates ER stress-stimulated collagen production in cardiac fibroblasts by inhibiting CHOP-mediated NF-κB expression

Inflammation and cardiac fibrosis are prevalent pathophysiologic conditions associated with hypertension, cardiac remodeling, and heart failure. Endoplasmic reticulum (ER) stress triggers the cells to activate unfolded protein responses (UPRs) and upregulate the ER stress chaperon, enzymes, and down...

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Bibliographic Details
Main Authors: Hamid Suhail, Hongmei Peng, Khalid Matrougui, Nour-Eddine Rhaleb
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Pharmacology
Subjects:
Ac-SDKP
ER stress
UPRs
inflammation
collagen
human cardiac fibroblast
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1352222/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2024.1352222/full

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