Apoptosis-mediated ADAM10 activation removes a mucin barrier promoting T cell efferocytosis

Apoptosis-mediated ADAM10 activation removes a mucin barrier promoting T cell efferocytosis

Abstract Efferocytic clearance of apoptotic cells in general, and T cells in particular, is required for tissue and immune homeostasis. Transmembrane mucins are extended glycoproteins highly expressed in the cell glycocalyx that function as a barrier to phagocytosis. Whether and how mucins may be re...

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Bibliographic Details
Main Authors: Linnea Z. Drexhage, Shengpan Zhang, Maeva Dupont, Franziska Ragaller, Ellen Sjule, Jose Cabezas-Caballero, Lachlan P. Deimel, Helen Robertson, Rebecca A. Russell, Omer Dushek, Erdinc Sezgin, Niloofar Karaji, Quentin J. Sattentau
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-44619-8

Internet

https://doi.org/10.1038/s41467-023-44619-8

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