The Role of Macroautophagy and Chaperone-Mediated Autophagy in the Pathogenesis and Management of Hepatocellular Carcinoma
Hepatocarcinogenesis is a long process with a complex pathophysiology. The current therapeutic options for HCC management, during the advanced stage, provide short-term survival ranging from 10–14 months. Autophagy acts as a double-edged sword during this process. Recently, two main autophagic pathw...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/3/760 |
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| author | Anastasia D. Karampa Anna C. Goussia Georgios K. Glantzounis Eleftheria M. Mastoridou Nikolaos-Andreas T. Anastasopoulos Antonia V. Charchanti |
| author_facet | Anastasia D. Karampa Anna C. Goussia Georgios K. Glantzounis Eleftheria M. Mastoridou Nikolaos-Andreas T. Anastasopoulos Antonia V. Charchanti |
| author_sort | Anastasia D. Karampa |
| collection | DOAJ |
| description | Hepatocarcinogenesis is a long process with a complex pathophysiology. The current therapeutic options for HCC management, during the advanced stage, provide short-term survival ranging from 10–14 months. Autophagy acts as a double-edged sword during this process. Recently, two main autophagic pathways have emerged to play critical roles during hepatic oncogenesis, macroautophagy and chaperone-mediated autophagy. Mounting evidence suggests that upregulation of macroautophagy plays a crucial role during the early stages of carcinogenesis as a tumor suppressor mechanism; however, it has been also implicated in later stages promoting survival of cancer cells. Nonetheless, chaperone-mediated autophagy has been elucidated as a tumor-promoting mechanism contributing to cancer cell survival. Moreover, the autophagy pathway seems to have a complex role during the metastatic stage, while induction of autophagy has been implicated as a potential mechanism of chemoresistance of HCC cells. The present review provides an update on the role of autophagy pathways in the development of HCC and data on how the modulation of the autophagic pathway could contribute to the most effective management of HCC. |
| first_indexed | 2024-03-10T00:06:31Z |
| format | Article |
| id | doaj.art-a78ddbd5b5b14b7991be14d9d185da69 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T00:06:31Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-a78ddbd5b5b14b7991be14d9d185da692023-11-23T16:08:14ZengMDPI AGCancers2072-66942022-02-0114376010.3390/cancers14030760The Role of Macroautophagy and Chaperone-Mediated Autophagy in the Pathogenesis and Management of Hepatocellular CarcinomaAnastasia D. Karampa0Anna C. Goussia1Georgios K. Glantzounis2Eleftheria M. Mastoridou3Nikolaos-Andreas T. Anastasopoulos4Antonia V. Charchanti5HPB Unit, Department of Surgery, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45500 Ioannina, GreeceDepartment of Pathology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45500 Ioannina, GreeceHPB Unit, Department of Surgery, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45500 Ioannina, GreeceDepartment of Anatomy-Histology-Embryology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45500 Ioannina, GreeceHPB Unit, Department of Surgery, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45500 Ioannina, GreeceDepartment of Anatomy-Histology-Embryology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45500 Ioannina, GreeceHepatocarcinogenesis is a long process with a complex pathophysiology. The current therapeutic options for HCC management, during the advanced stage, provide short-term survival ranging from 10–14 months. Autophagy acts as a double-edged sword during this process. Recently, two main autophagic pathways have emerged to play critical roles during hepatic oncogenesis, macroautophagy and chaperone-mediated autophagy. Mounting evidence suggests that upregulation of macroautophagy plays a crucial role during the early stages of carcinogenesis as a tumor suppressor mechanism; however, it has been also implicated in later stages promoting survival of cancer cells. Nonetheless, chaperone-mediated autophagy has been elucidated as a tumor-promoting mechanism contributing to cancer cell survival. Moreover, the autophagy pathway seems to have a complex role during the metastatic stage, while induction of autophagy has been implicated as a potential mechanism of chemoresistance of HCC cells. The present review provides an update on the role of autophagy pathways in the development of HCC and data on how the modulation of the autophagic pathway could contribute to the most effective management of HCC.https://www.mdpi.com/2072-6694/14/3/760hepatocellular carcinomamacroautophagychaperone-mediated autophagychemoresistance |
| spellingShingle | Anastasia D. Karampa Anna C. Goussia Georgios K. Glantzounis Eleftheria M. Mastoridou Nikolaos-Andreas T. Anastasopoulos Antonia V. Charchanti The Role of Macroautophagy and Chaperone-Mediated Autophagy in the Pathogenesis and Management of Hepatocellular Carcinoma Cancers hepatocellular carcinoma macroautophagy chaperone-mediated autophagy chemoresistance |
| title | The Role of Macroautophagy and Chaperone-Mediated Autophagy in the Pathogenesis and Management of Hepatocellular Carcinoma |
| title_full | The Role of Macroautophagy and Chaperone-Mediated Autophagy in the Pathogenesis and Management of Hepatocellular Carcinoma |
| title_fullStr | The Role of Macroautophagy and Chaperone-Mediated Autophagy in the Pathogenesis and Management of Hepatocellular Carcinoma |
| title_full_unstemmed | The Role of Macroautophagy and Chaperone-Mediated Autophagy in the Pathogenesis and Management of Hepatocellular Carcinoma |
| title_short | The Role of Macroautophagy and Chaperone-Mediated Autophagy in the Pathogenesis and Management of Hepatocellular Carcinoma |
| title_sort | role of macroautophagy and chaperone mediated autophagy in the pathogenesis and management of hepatocellular carcinoma |
| topic | hepatocellular carcinoma macroautophagy chaperone-mediated autophagy chemoresistance |
| url | https://www.mdpi.com/2072-6694/14/3/760 |
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