Mutations of PI3K-AKT-mTOR pathway as predictors for immune cell infiltration and immunotherapy efficacy in dMMR/MSI-H gastric adenocarcinoma

Mutations of PI3K-AKT-mTOR pathway as predictors for immune cell infiltration and immunotherapy efficacy in dMMR/MSI-H gastric adenocarcinoma

Abstract Background A significant subset of mismatch repair-deficient (dMMR)/microsatellite instability-high (MSI-H) gastric adenocarcinomas (GAC) are resistant to immune checkpoint inhibitors (ICIs), yet the underlying mechanism remains largely unknown. We sought to investigate the genomic correlat...

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Bibliographic Details
Main Authors: Zhenghang Wang, Xinyu Wang, Yu Xu, Jian Li, Xiaotian Zhang, Zhi Peng, Yajie Hu, Xinya Zhao, Kun Dong, Bei Zhang, Chan Gao, Xiaochen Zhao, Hui Chen, Jinping Cai, Yuezong Bai, Yu Sun, Lin Shen
Format: Article
Language:English
Published: BMC 2022-04-01
Series:BMC Medicine
Subjects:
dMMR/MSI-H gastric adenocarcinoma
PI3K-AKT-mTOR pathway
Tumor-infiltrating immune cell
Immune checkpoint inhibitor
Online Access:https://doi.org/10.1186/s12916-022-02327-y

Internet

https://doi.org/10.1186/s12916-022-02327-y

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