Imbalanced pattern completion vs. separation in cognitive disease: network simulations of synaptic pathologies predict a personalized therapeutics strategy

<p>Abstract</p> <p>Background</p> <p>Diverse Mouse genetic models of neurodevelopmental, neuropsychiatric, and neurodegenerative causes of impaired cognition exhibit at least four convergent points of synaptic malfunction: 1) Strength of long-term potentiation (LTP), 2)...

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Bibliographic Details
Main Authors: Hanson Jesse E, Madison Daniel V
Format: Article
Language:English
Published: BMC 2010-08-01
Series:BMC Neuroscience
Online Access:http://www.biomedcentral.com/1471-2202/11/96