Increased Hippocampal ProBDNF Contributes to Memory Impairments in Aged Mice

Increased Hippocampal ProBDNF Contributes to Memory Impairments in Aged Mice

Memory decline during aging or accompanying neurodegenerative diseases, represents a major health problem. Neurotrophins have long been considered relevant to the mechanisms of aging-associated cognitive decline and neurodegeneration. Mature Brain-Derived Neurotrophic Factor (BDNF) and its precursor...

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Bibliographic Details
Main Authors: Mona Buhusi, Chris Etheredge, Ann-Charlotte Granholm, Catalin V. Buhusi
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Aging Neuroscience
Subjects:
BDNF
proBDNF
p75NTR
TAT-Pep5
memory
cofilin
Online Access:http://journal.frontiersin.org/article/10.3389/fnagi.2017.00284/full

Internet

http://journal.frontiersin.org/article/10.3389/fnagi.2017.00284/full

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