KDM4C-mediated senescence defense is a targetable vulnerability in gastric cancer harboring TP53 mutations

KDM4C-mediated senescence defense is a targetable vulnerability in gastric cancer harboring TP53 mutations

Abstract Background Gastric cancer patients harboring a TP53 mutation exhibit a more aggressive and chemoresistant phenotype. Unfortunately, efforts to identify the vulnerabilities to overcome these aggressive malignancies have made minimal progress in recent years. Therefore, there is an urgent nee...

Full description

Bibliographic Details
Main Authors: Kaiqing Wang, Zhicheng Gong, Yanyan Chen, Meimei Zhang, Suzeng Wang, Surui Yao, Zhihui Liu, Zhaohui Huang, Bojian Fei
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Clinical Epigenetics
Subjects:
Gastric cancer
TP53 mutation
Epigenetic
Senescence
Senolytics
Online Access:https://doi.org/10.1186/s13148-023-01579-6

Internet

https://doi.org/10.1186/s13148-023-01579-6

Similar Items