Activation of locus coeruleus heme oxygenase-carbon monoxide pathway promoted an anxiolytic-like effect in rats

Activation of locus coeruleus heme oxygenase-carbon monoxide pathway promoted an anxiolytic-like effect in rats

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The heme oxygenase-carbon monoxide pathway has been shown to play an important role in many physiological processes and is capable of altering nociception modulation in the nervous system by stimulating soluble guanylate cyclase (sGC). In the central nervous system, the locus coeruleus (LC) is known...

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Bibliographic Details
Main Authors: P.G. Carvalho-Costa, L.G.S. Branco, C.R.A. Leite-Panissi
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2016-04-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Heme oxygenase
Carbon monoxide
Locus coeruleus
Anxiety
Elevated plus maze, Light/dark box
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000500601&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000500601&tlng=en

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