The Gαs‐protein‐mediated pathway may be steadily stimulated by prostanoid EP2 receptors, but not by EP4 receptors

The Gαs‐protein‐mediated pathway may be steadily stimulated by prostanoid EP2 receptors, but not by EP4 receptors

EP2 and EP4 prostanoid receptors have long been considered to have similar roles, since they are known to couple with Gαs‐protein and activate cAMP‐mediated signaling pathways. In this study, we re‐evaluated the results of cAMP assays with or without phosphodiesterase (PDE) inhibitor pretreatment. H...

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Manylion Llyfryddiaeth
Prif Awduron: Keijo Fukushima, Kanaho Senoo, Naoki Kurata, John W. Regan, Hiromichi Fujino
Fformat: Erthygl
Iaith:English
Cyhoeddwyd: Wiley 2022-04-01
Cyfres:FEBS Open Bio
Pynciau:
biased signaling
black/Leff operational model calculation
cAMP
PDE
prostanoid EP2 receptor
prostanoid EP4 receptor
Mynediad Ar-lein:https://doi.org/10.1002/2211-5463.13378

Rhyngrwyd

https://doi.org/10.1002/2211-5463.13378

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