PA-X protein of H1N1 subtype influenza virus disables the nasal mucosal dendritic cells for strengthening virulence

PA-X protein of H1N1 subtype influenza virus disables the nasal mucosal dendritic cells for strengthening virulence

PA-X protein arises from a ribosomal frameshift in the PA of influenza A virus (IAV). However, the immune regulatory effect of the PA-X protein of H1N1 viruses on the nasal mucosal system remains unclear. Here, a PA-X deficient H1N1 rPR8 viral strain (rPR8-△PAX) was generated and its pathogenicity w...

Full description

Bibliographic Details
Main Authors: Tao Qin, Yulian Chen, Dandan Huangfu, Yinyan Yin, Xinyu Miao, Yuncong Yin, Sujuan Chen, Daxin Peng, Xiufan Liu
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Virulence
Subjects:
Influenza A virus
H1N1
PA-X protein
dendritic cells
innate immunity
virulence
Online Access:https://www.tandfonline.com/doi/10.1080/21505594.2022.2139474

Internet

https://www.tandfonline.com/doi/10.1080/21505594.2022.2139474

Similar Items