Notch Signaling and Cross-Talk in Hypoxia: A Candidate Pathway for High-Altitude Adaptation

Notch Signaling and Cross-Talk in Hypoxia: A Candidate Pathway for High-Altitude Adaptation

Hypoxia triggers complex inter- and intracellular signals that regulate tissue oxygen (O<sub>2</sub>) homeostasis, adjusting convective O<sub>2</sub> delivery and utilization (i.e., metabolism). Human populations have been exposed to high-altitude hypoxia for thousands of yea...

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Bibliographic Details
Main Authors: Katie A. O’Brien, Andrew J. Murray, Tatum S. Simonson
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Life
Subjects:
hypobaric hypoxia
adaptation
Notch signaling
hypoxia-inducible factor
Online Access:https://www.mdpi.com/2075-1729/12/3/437

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