Piperlongumine Inhibits Titanium Particles-Induced Osteolysis, Osteoclast Formation, and RANKL-Induced Signaling Pathways

Piperlongumine Inhibits Titanium Particles-Induced Osteolysis, Osteoclast Formation, and RANKL-Induced Signaling Pathways

Wear particle-induced aseptic loosening is the most common complication of total joint arthroplasty (TJA). Excessive osteoclast formation and bone resorptive activation have been considered to be responsible for extensive bone destruction and prosthesis failure. Therefore, identification of anti-ost...

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Bibliographic Details
Main Authors: Xuan Liu, Li Diao, Yudie Zhang, Xue Yang, Junnan Zhou, Yuhang Mao, Xiaotian Shi, Fuli Zhao, Mei Liu
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:International Journal of Molecular Sciences
Subjects:
piperlongumine
osteoclast formation
bone resorption
RANKL-induced signaling pathways
osteolysis
Online Access:https://www.mdpi.com/1422-0067/23/5/2868

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https://www.mdpi.com/1422-0067/23/5/2868

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