Combining ablative radiotherapy and anti CD47 monoclonal antibody improves infiltration of immune cells in tumor microenvironments.

Combining ablative radiotherapy and anti CD47 monoclonal antibody improves infiltration of immune cells in tumor microenvironments.

Radiotherapy as an anti-tumor treatment can stimulate the immune system. However, irradiated tumor cells express CD47 to escape the anti-tumor immune response. Anti- CD47 Immunotherapy is a possible way to tackle this problem. This study evaluated the effect of single high dose radiotherapy combined...

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Bibliographic Details
Main Authors: Elham Rostami, Mohsen Bakhshandeh, Haniyeh Ghaffari-Nazari, Maedeh Alinezhad, Masoumeh Alimohammadi, Reza Alimohammadi, Ghanbar Mahmoodi Chalbatani, Ehsan Hejazi, Thomas J Webster, Jalil Tavakkol-Afshari, Seyed Amir Jalali
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0273547

Internet

https://doi.org/10.1371/journal.pone.0273547

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