Akt Protein Kinase, miR-200/miR-182 Expression and Epithelial-Mesenchymal Transition Proteins in Hibernating Ground Squirrels

Akt Protein Kinase, miR-200/miR-182 Expression and Epithelial-Mesenchymal Transition Proteins in Hibernating Ground Squirrels

Hibernating 13-lined ground squirrels (Ictidomys tridecemlineatus; TLGS) rank among the most brain hypoperfusion-tolerant mammals known. Herein we provide some evidence of cycling between an epithelial phenotype and a hybrid epithelial/mesenchymal (E/M) phenotype (partial EMT) within the brains of T...

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Bibliographic Details
Main Authors: Yang-ja Lee, Joshua D. Bernstock, Dace Klimanis, John M. Hallenbeck
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Molecular Neuroscience
Subjects:
brain ischemia
cellular reprogramming
epithelial-mesenchymal transition (EMT)
hibernation
ischemic tolerance
miR-200 family
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2018.00022/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2018.00022/full

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