An ultraviolet-driven rescue pathway for oxidative stress to eye lens protein human gamma-D crystallin

An ultraviolet-driven rescue pathway for oxidative stress to eye lens protein human gamma-D crystallin

Abstract Human gamma-D crystallin (HGD) is a major constituent of the eye lens. Aggregation of HGD contributes to cataract formation, the leading cause of blindness worldwide. It is unique in its longevity, maintaining its folded and soluble state for 50-60 years. One outstanding question is the str...

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Bibliographic Details
Main Authors: Jake A. Hill, Yvonne Nyathi, Sam Horrell, David von Stetten, Danny Axford, Robin L. Owen, Godfrey S. Beddard, Arwen R. Pearson, Helen M. Ginn, Briony A. Yorke
Format: Article
Language:English
Published: Nature Portfolio 2024-04-01
Series:Communications Chemistry
Online Access:https://doi.org/10.1038/s42004-024-01163-w

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https://doi.org/10.1038/s42004-024-01163-w

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