The immunomodulatory effect of oral NaHCO3 is mediated by the splenic nerve: multivariate impact revealed by artificial neural networks

The immunomodulatory effect of oral NaHCO3 is mediated by the splenic nerve: multivariate impact revealed by artificial neural networks

Abstract Stimulation of the inflammatory reflex (IR) is a promising strategy for treating systemic inflammatory disorders. Recent studies suggest oral sodium bicarbonate (NaHCO3) as a potential activator of the IR, offering a safe and cost-effective treatment approach. However, the mechanisms underl...

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Bibliographic Details
Main Authors: Milena Rodriguez Alvarez, Hussam Alkaissi, Aja M. Rieger, Guillem R. Esber, Manuel E. Acosta, Stacy I. Stephenson, Allison V. Maurice, Laura Melissa Rodríguez Valencia, Christopher A. Roman, Juan Marcos Alarcon
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Journal of Neuroinflammation
Subjects:
Inflammatory reflex (IR)
Sodium bicarbonate (NaHCO3)
Artificial neural networks
Splenic nerve
Spleen denervation
Cholinergic splenic anti-inflammatory pathway (CSAP)
Online Access:https://doi.org/10.1186/s12974-024-03067-x

Internet

https://doi.org/10.1186/s12974-024-03067-x

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