Vaccine Efficacy of Self-Assembled Multimeric Protein Scaffold Particles Displaying the Glycoprotein Gn Head Domain of Rift Valley Fever Virus

Vaccine Efficacy of Self-Assembled Multimeric Protein Scaffold Particles Displaying the Glycoprotein Gn Head Domain of Rift Valley Fever Virus

Compared to free antigens, antigens immobilized on scaffolds, such as nanoparticles, generally show improved immunogenicity. Conventionally, antigens are conjugated to scaffolds through genetic fusion or chemical conjugation, which may result in impaired assembly or heterogeneous binding and orienta...

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Bibliographic Details
Main Authors: Paul J. Wichgers Schreur, Mirriam Tacken, Benjamin Gutjahr, Markus Keller, Lucien van Keulen, Jet Kant, Sandra van de Water, Yanyin Lin, Martin Eiden, Melanie Rissmann, Felicitas von Arnim, Rebecca König, Alexander Brix, Catherine Charreyre, Jean-Christophe Audonnet, Martin H. Groschup, Jeroen Kortekaas
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Vaccines
Subjects:
Rift Valley fever virus
bacterial superglue
multimeric protein scaffold particles
sheep
Gn head domain
Online Access:https://www.mdpi.com/2076-393X/9/3/301

Internet

https://www.mdpi.com/2076-393X/9/3/301

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