Glucagon receptor antagonism impairs and glucagon receptor agonism enhances triglycerides metabolism in mice

Glucagon receptor antagonism impairs and glucagon receptor agonism enhances triglycerides metabolism in mice

Objective: Treatment with glucagon receptor antagonists (GRAs) reduces blood glucose but causes dyslipidemia and accumulation of fat in the liver. We investigated the acute and chronic effects of glucagon on lipid metabolism in mice. Methods: Chronic effects of glucagon receptor signaling on lipid m...

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Bibliographic Details
Main Authors: Katrine D. Galsgaard, Emilie Elmelund, Christian D. Johansen, Anna B. Bomholt, Hüsün S. Kizilkaya, Frederik Ceutz, Jenna E. Hunt, Hannelouise Kissow, Marie Winther-Sørensen, Charlotte M. Sørensen, Thomas Kruse, Jesper F. Lau, Mette M. Rosenkilde, Cathrine Ørskov, Christina Christoffersen, Jens J. Holst, Nicolai J. Wewer Albrechtsen
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Molecular Metabolism
Subjects:
Cholesterol
Glucagon
Non-esterified/ free fatty acids
Steatosis
Triglycerides
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877822002083

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http://www.sciencedirect.com/science/article/pii/S2212877822002083

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