Concentration of non-myocyte proteins in arterial media of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.

Concentration of non-myocyte proteins in arterial media of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.

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The most common inherited cause of vascular dementia and stroke, cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), is caused by mutations in NOTCH3. Post-translationally altered NOTCH3 accumulates in the vascular media of CADASIL arteries in areas...

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Bibliographic Details
Main Authors: Soo Jung Lee, Akhil Kondepudi, Kelly Z Young, Xiaojie Zhang, Naw May Pearl Cartee, Jijun Chen, Krystal Yujin Jang, Gang Xu, Jimo Borjigin, Michael M Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0281094

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https://doi.org/10.1371/journal.pone.0281094

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