Maintaining Toll signaling in Drosophila brain is required to sustain autophagy for dopamine neuron survival

Summary: Macroautophagy/autophagy is a conserved process in eukaryotic cells to degrade and recycle damaged intracellular components. Higher level of autophagy in the brain has been observed, and autophagy dysfunction has an impact on neuronal health, but the molecular mechanism is unclear. In this...

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Bibliographic Details
Main Authors: Jie Zhang, Ting Tang, Ruonan Zhang, Liang Wen, Xiaojuan Deng, Xiaoxia Xu, Wanying Yang, Fengliang Jin, Yang Cao, Yuzhen Lu, Xiao-Qiang Yu
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224000166