Lipid Metabolism Reprogramming and Trastuzumab Resistance in Breast Cancer Cell Lines Overexpressing the ERBB2 Membrane Receptor

Lipid Metabolism Reprogramming and Trastuzumab Resistance in Breast Cancer Cell Lines Overexpressing the ERBB2 Membrane Receptor

Trastuzumab (Tz), an antibody targeting ERBB2, has significantly improved the prognosis for breast cancer (BCa) patients with overexpression of the ERBB2 receptor. However, Tz resistance poses a challenge to patient outcomes. Numerous mechanisms have been suggested to contribute to Tz resistance, an...

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Bibliographic Details
Main Authors: Katia Cortese, Marco Ponassi, Aldo Profumo, Gabriela Coronel Vargas, Erika Iervasi, Maria Cristina Gagliani, Grazia Bellese, Sara Tavella, Patrizio Castagnola
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Membranes
Subjects:
trastuzumab
trastuzumab resistance
HER2
breast cancer
proteomic analysis
metabolic reprogramming
Online Access:https://www.mdpi.com/2077-0375/13/6/540

Internet

https://www.mdpi.com/2077-0375/13/6/540

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