Transcriptional alterations of protein coding and noncoding RNAs in triple negative breast cancer in response to DNA methyltransferases inhibition

Transcriptional alterations of protein coding and noncoding RNAs in triple negative breast cancer in response to DNA methyltransferases inhibition

Abstract Background DNA methylation plays a crucial role in multiple cellular processes such as gene regulation, chromatin stability, and genetic imprinting. In mammals, DNA methylation is achieved by DNA methyltransferases (DNMTs). A number of studies have associated alterations in DNMT activity to...

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Bibliographic Details
Main Authors: Ramesh Elango, Radhakrishnan Vishnubalaji, Hibah Shaath, Nehad M. Alajez
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Cancer Cell International
Subjects:
TNBC
Decitabine
5-Azacytidine
DNA methyltransferase
lncRNA
TPT1-AS1
Online Access:https://doi.org/10.1186/s12935-021-02213-2

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