Trehalose Alleviates Crystalline Silica-Induced Pulmonary Fibrosis via Activation of the TFEB-Mediated Autophagy-Lysosomal System in Alveolar Macrophages

Trehalose Alleviates Crystalline Silica-Induced Pulmonary Fibrosis via Activation of the TFEB-Mediated Autophagy-Lysosomal System in Alveolar Macrophages

Silicosis is an occupational lung disease characterized by persistent inflammation and irreversible fibrosis. Crystalline silica (CS) particles are mainly phagocytized by alveolar macrophages (AMs), which trigger apoptosis, inflammation, and pulmonary fibrosis. Previously, we found that autophagy-ly...

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Bibliographic Details
Main Authors: Xiu He, Shi Chen, Chao Li, Jiaqi Ban, Yungeng Wei, Yangyang He, Fangwei Liu, Ying Chen, Jie Chen
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Cells
Subjects:
tfeb
trehalose
silicosis
alveolar macrophages
autophagy
lysosome
Online Access:https://www.mdpi.com/2073-4409/9/1/122

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https://www.mdpi.com/2073-4409/9/1/122

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