Mitochondrial UQCC3 controls embryonic and tumor angiogenesis by regulating VEGF expression

Mitochondrial UQCC3 controls embryonic and tumor angiogenesis by regulating VEGF expression

Summary: Mitochondria play important roles in angiogenesis. However, the mechanisms remain elusive. In this study, we found that mitochondrial ubiquinol-cytochrome c reductase complex assembly factor 3 (UQCC3) is a key regulator of angiogenesis. TALEN-mediated knockout of Uqcc3 in mice caused embryo...

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Bibliographic Details
Main Authors: Guimin Zhang, Binrui Liu, Yun Yang, Shuo Xie, Lingcheng Chen, Hui Luo, Jian Zhong, Yinhao Wei, Fengzhu Guo, Jia Gan, Fan Zhu, Lin Xu, Qiqi Li, Yuge Shen, Huajin Zhang, Yan Liu, Rong Li, Hongxin Deng, Hanshuo Yang
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:iScience
Subjects:
Biological sciences
Cancer systems biology
Natural sciences
Systems biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223014475

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http://www.sciencedirect.com/science/article/pii/S2589004223014475

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