Mitochondrial UQCC3 controls embryonic and tumor angiogenesis by regulating VEGF expression

Summary: Mitochondria play important roles in angiogenesis. However, the mechanisms remain elusive. In this study, we found that mitochondrial ubiquinol-cytochrome c reductase complex assembly factor 3 (UQCC3) is a key regulator of angiogenesis. TALEN-mediated knockout of Uqcc3 in mice caused embryo...

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Main Authors: Guimin Zhang, Binrui Liu, Yun Yang, Shuo Xie, Lingcheng Chen, Hui Luo, Jian Zhong, Yinhao Wei, Fengzhu Guo, Jia Gan, Fan Zhu, Lin Xu, Qiqi Li, Yuge Shen, Huajin Zhang, Yan Liu, Rong Li, Hongxin Deng, Hanshuo Yang
格式: 文件
语言:English
出版: Elsevier 2023-08-01
丛编:iScience
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在线阅读:http://www.sciencedirect.com/science/article/pii/S2589004223014475