Improved Boron Neutron Capture Therapy Using Integrin αvβ3-Targeted Long-Retention-Type Boron Carrier in a F98 Rat Glioma Model

Improved Boron Neutron Capture Therapy Using Integrin αvβ3-Targeted Long-Retention-Type Boron Carrier in a F98 Rat Glioma Model

Integrin α<sub>v</sub>β<sub>3</sub> is more highly expressed in high-grade glioma cells than in normal tissues. In this study, a novel boron-10 carrier containing maleimide-functionalized <i>closo</i>-dodecaborate (MID), serum albumin as a drug delivery system, an...

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Bibliographic Details
Main Authors: Kohei Tsujino, Hideki Kashiwagi, Kai Nishimura, Ryo Kayama, Kohei Yoshimura, Yusuke Fukuo, Hiroyuki Shiba, Ryo Hiramatsu, Naosuke Nonoguchi, Motomasa Furuse, Toshihiro Takami, Shin-Ichi Miyatake, Naonori Hu, Takushi Takata, Hiroki Tanaka, Minoru Suzuki, Shinji Kawabata, Hiroyuki Nakamura, Masahiko Wanibuchi
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Biology
Subjects:
boron neutron capture therapy (BNCT)
glioma
integrin
cyclic arginine-glycine-aspartate
biological target
albumin
Online Access:https://www.mdpi.com/2079-7737/12/3/377

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https://www.mdpi.com/2079-7737/12/3/377

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