Construction of pseudorabies virus variant attenuated vaccine: codon deoptimization of US3 and UL56 genes based on PRV gE/TK deletion strain

Construction of pseudorabies virus variant attenuated vaccine: codon deoptimization of US3 and UL56 genes based on PRV gE/TK deletion strain

Since 2011, pseudorabies based on the pseudorabies virus (PRV) variant has emerged as a serious health issue in pig farms in China. The PRV gE/TK or gE/gI/TK deletion strains protect against emerging PRV variants. However, these variants may cause lethal infections in newborn piglets without PRV ant...

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Bibliographic Details
Main Authors: Mengwei Xu, Laixu Zhu, Aimin Ge, Yamei Liu, Saisai Chen, Ziwen Wei, Yating Zheng, Ling Tong, Zhisheng Wang, Rongmei Fei, Jichun Wang, Chuanjian Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Microbiology
Subjects:
pseudorabies virus
attenuation
immunogenicity
codon deoptimization
US3-S
UL56
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2023.1248573/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2023.1248573/full

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