CSF1R Inhibition Reduces Microglia Proliferation, Promotes Tissue Preservation and Improves Motor Recovery After Spinal Cord Injury

CSF1R Inhibition Reduces Microglia Proliferation, Promotes Tissue Preservation and Improves Motor Recovery After Spinal Cord Injury

Spinal cord injury (SCI) induces a pronounced neuroinflammation driven by activation and proliferation of resident microglia as well as infiltrating peripheral monocyte-derived macrophages. Depending on the time post-lesion, positive and detrimental influences of microglia/macrophages on axonal rege...

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Detalhes bibliográficos
Principais autores: Yannick Nicolas Gerber, Guillaume Patrick Saint-Martin, Claire Mathilde Bringuier, Sylvain Bartolami, Christophe Goze-Bac, Harun Najib Noristani, Florence Evelyne Perrin
Formato: Artigo
Idioma:English
Publicado em: Frontiers Media S.A. 2018-10-01
coleção:Frontiers in Cellular Neuroscience
Assuntos:
spinal cord injury
reduced microglia proliferation
colony stimulating factor 1 receptor
GW2580
motor recovery
reduced gliosis
Acesso em linha:https://www.frontiersin.org/article/10.3389/fncel.2018.00368/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2018.00368/full

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